What is the answer to "Most significant" in the Newsday Crossword?

The answer to the Newsday Crossword clue "Most significant" is MAIN (4 letters).

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Most significant Newsday Crossword Clue

Down clue · from the May 18, 2025 puzzle

Stuck on “Most significant” from the Newsday Crossword? Here is the verified answer:

Answer

MAIN

4 letters · Down · last seen May 18, 2025

Newsday December 28 2025MAIN Newsday May 18 2025MAIN

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